RaQualia Pharma [4579]

Pipelines

Updated on 7 1, 2019

Completed
On planning
On going
Launch
Plan
Project Compound
(Generic name)
Indication Partnered party Discovery Pre-Clin, Clinical Studies NDA Approval Sales Territory Remarks
Phase 1 Phase 2 Phase 3
PotassiumCompetitive acid blocker
(P-CAB)
RQ-00000004
(Tegoprazan)
CJ-12420 [CJ HealthCare]
LXI-15028 [Luoxin Pharma]
GERD
(RE/NERD)
-
Completed P1
USA
Japan
CJ HealthCare
Launch (March 2019)
Korea Product name: K-CAB
Co-promotion with Chong Kun Dang Pharmaceutical Corp.
Blockbuster expectation with annual sales of 100 billion won.
On going P3
Launch
2021-2022
China Re-contracted: CJ HealthCare => Luoxin Pharma
Market Size (China): 260 billion yen (2 billion 600 million USD) *Investigation of RaQualia
Preparation NDA
Launch
2021
Vietnam Re-contracted: CJ HealthCare => Vimedimex Medi-Pharma JSC
Related information
Preparation NDA
Launch
2022 (Mexico)
Latin America
17 countries
(Mexico, Argentina etc.)
Re-contracted: CJ HealthCare => Laboratorios Carnot
Related information
ROW ROW: Latin America (Brazil etc.), East European, Middle East
Taiwan
Southeast Asia
CRHR2 antagonist - Heart failure Nagoya University
(Collaborative Research)
On going
Japan Discovered lead compounds and started an investigation of preclinical efficacy.
This research plans to complete the research phase from the end of 2019 to 2020. [Reference]
TRPM8 blocker RQ-00434739 Neuropathic pain -
On planning
Japan
P2X7 receptor antagonist RQ-00466479
AKP-23494954 [Asahi Kasei Pharma]
Neuropathic pain Asahi Kasei Pharma
On going
Global Diabetic neuropathic medicine, herpes virus infective neuropathic medicine. It is conducting tests to establish long-term toxicity tests and industrial synthesis methods. Clinical trial schedule for people in 2019. [Reference]
Selective sodium channel blocker - Analgesia
Pruritus
Maruho
On going
Global
- Pain -
Discovery
Japan
Ion channel - Gastrointestinal EA Pharma
On going
Japan
Ion channel - - ASKA Pharmaceutical
(Collaborative Research)
Collab
Japan
Sodium channel Nav1.7 selective blocker RQ-00488738 Pain - - Product of collaboration with XuanZhu Pharma
protein-protein interaction inhibitor On Identity Test Pain Interprotein
(Collaborative Research)
On going
Japan
5-HT4 partial agonist RQ-00000010 Gastroparesis
Functional dyspepsia
Chronic Constipation
-
Completed P1
UK Mosapride's sales amount of peak tops is 21.2 billion yen (Japan)
Gastroparesis -
Investigator Clinical Trial
USA Collaboration with Virginia Commonwealth University (VCU) Parkinson's and Movement Disorders Center
RQ-00000009
AAT-009 [AskAt]
Alzheimer's AskAt
Completed P1 (U.S.)
Global
5-HT2B antagonist RQ-00310941 IBS-D -
Completed P1
UK
Motilin receptor agonist RQ-00201894 Gastroparesis
Functional dyspepsia
Post - operative Ileus
-
On planning P1
Japan
Ghrelin receptor agonist RQ-00000005
(Capromorelin)
AT-002 [Aratana]
Weight loss, Anorexia: Dog Aratana Therapeutics
(Global (Animal))
Launch (October 2017)
USA Product name: Entyce®
Approval (2019)
Launch
2020
Europe
Weight loss, Anorexia: Cat
Pivotal study
USA
RQ-00433412 Anorexia associated with cancer -
On planning
Japan
Ziprasidone RQ-00000003
(Ziprasidone Hydrochloride Monohydrate)
ME2112 [Meiji Seika Pharma]
Schizophrenia Meiji Seika Pharma
On going P3
NDA
2019
Launch
2020
Japan Market Size (Japan): 160 Billion Yen *Investigation of RaQualia
EP4 antagonist RQ-00000007
(Grapiprant)
AAT-007 [AskAt]
AT-001 [Aratana]
ARY-007 [Arrys]
RMX1002 [RMX]
Osteoarthritis: Dog Aratana Therapeutics
(Global (Animal))
Launch (USA: Jan. 2017, Europe: Mar. 2019)
USA
Europe
Product name: Galliprant®
With this product Aratana makes strategic alliance with Elanco
MSS Colorectal Cancer AskAt
(Global (Excluding animal))
USA Re-contracted: AskAt => Arrys Therapeutics (Global excluding China and Taiwan)
Development: Arrys affiliate Kyn Therapeutics
Clinical study with grapiprant in combination with pembrolizumab(anti PD-1 antibody, KEYTRUDA).
NSCLC Adenocarcinoma
Cancer
On going P1
China Re-contracted: AskAt => Ningbo Tai Kang Medical Technology
Development: Ningbo NewBay Medical Technology
Pain
Completed P2a
USA
Completed P1
China Re-contracted: AskAt => RMX Biopharma
Development: A joint venture between Shanghai HaiHe Biopharma and China Shijiazhuang Holding Group [Reference]
RQ-00000008
AAT-008 [AskAt]
AT-019 [Aratana]
Animal AskAt
(Global)
Started transferring the manufacturing process of the API and early formulation work (early-2019)
Global Re-contracted: AskAt => Aratana
Cancer
On planning P1
USA Re-contracted: AskAt => Arrys Therapeutics (Global excluding China and Taiwan)
China Re-contracted: AskAt => Ningbo NewBay Medical Technology
COX-2 Inhibitor RQ-00317076
AAT-076 [AskAt]
RMX1001 [RMX]
Acute Pain AskAt
(Global)
Completed P2a
USA
On planning P1
China Re-contracted: AskAt => RMX Biopharma
Development: A joint venture between Shanghai HaiHe Biopharma and China Shijiazhuang Holding Group [Reference]

Other Pipelines

Updated on 4 5, 2019

Project Indication Partnered party Territory Remarks
CB2 agonist Pain
Immunology
AskAt
Dalbavancin MRSA Infections - Japan US product name: Dalvance
Anidulafungin Candida Infections - Japan US product name: Eraxis

Other Contracts

Updated on 12 15, 2018

Contractor Contract contents Remarks
H. Lundbeck A/S
(Denmark)
RaQualia Grants Patent License to H. Lundbeck Press release
Shire AG
(Swiss)
RaQualia Grants a Non-Exclusive Patent License to Shire AG For the Use of Ghrelin Receptor Agonist Press release
- RaQualia Pharma Joins DeNA & DeNA Life Science AI-Powered Drug Discovery Research Collaboration Press release

University Collaborative Research

Updated on 7 1, 2019

RaQualia Pharma Industry-Academia Collaborative Research Center

University Department Research theme Remarks
Nagoya University Department of Biochemistry, Graduate School of Medicine Search for selective inhibitors targeting specific enzymes for treatment of refractory neuroblastoma Press release
Department of Nephrology, Graduate School of Medicine Search for small molecule compounds inducing the secretion of cytokines and growth factors from adipose-derived stem cells Press release
Department of Cardiology, Graduate School of Medicine Search for selective inhibitors targeting specific proteins for treatment of heart failure Press release
Department of Respiratory Medicine, Graduate School of Medicine Search for novel therapeutic agents for KRAS mutated lung cancer Press release
Department of Biochemistry, Graduate School of Medicine Search for specific enzyme-selective inhibitors directed toward nerve regeneration Press release
Department of Brain Function, Research Institute for Environmental Medicine Mass spectrometry imaging and characterization of TRPM8 blocker RQ-00434739 in the brain Press release
Department of Molecular Medicine and Metabolism, Research Institute of Environmental Medicine Characterization of the mechanism of action of a novel small molecule compound targeting non-alcoholic steatohepatitis (NASH) Press release
Nagoya City University Department of Pathological Chemistry, Graduate School of Pharmaceutical Sciences Early search research for creation of new ALS therapeutic drug Press release
Gifu Pharmaceutical University Molecular Pharmacology, Department of Biofunctional Evaluation Evaluation of efficacy of a specific compound on glaucoma Press release
Molecular Pharmacology, Department of Biofunctional Evaluation Research on RVO (Retinal Vein Occlusion) Therapeutics Press release

TMRC (subsidiary) Pipeline

Updated on 12 4, 2018

Completed
On planning
On going
Launch
Plan
Project Compound
(Generic name)
Indication Partnered party Discovery Pre-Clin, Clinical Studies NDA Approval Sales Territory Remarks
Phase 1 Phase 2 Phase 3
TM-411 TM-411
(Tamibarotene)
SY-1425 [Syros Pharmaceuticals]
AML
(Acute myelogenous leukemia)
Syros Pharmaceuticals
On going P2 (Multiple drug combination)
USA Combination with azacitidine.Initial data.
AML & MDS (Myelodysplastic syndrome)
On going P2 (Multiple drug combination)
USA Combination with daratumumab.Initial data.
Breast cancer
(BS)
On planning P2
USA Scheduled to start taking into consideration the effectiveness of AML/MDS combination test
TM-411
(Tamibarotene)
OP-09 [Ohara Pharmaceutical]
Neuroblastoma
(NB)
Ohara Pharmaceutical
On going P1/2
Japan
Acute promyelocytic leukemia
(APL)
Toko Pharmaceutical Industrial
NDA
China
Neutropenia
(NP)
-
Completed
USA

Subsidiary

Updated on 4 24, 2019

Company name
TMRC Co., Ltd.
RaQualia Innovations Inc.

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